1,1'-Carbonyldiimidazole → HCID 178423976, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(5-methyl-2-thienyl)-5-methyl-4-thiazolecarboxylic acid (300 mg) and CDI (304.9 mg) in dry DMF (3 ml) was allowed to react at room temperature for 1 hour. Then a solution of 5-aminotetrazole (128 mg) in dry DMF (2 ml) was added dropwise and the mixture was heated at 70° C. for 3 hours. The solvent was removed from the reaction mixture, and the residue was treated with water and acidified with 2N-HCl under ice-cooling. The produced solids were filtered with suction, washed sufficiently with water and dried to give pale yellow solids of 2-(5-methyl-2-thienyl)-5-methyl-N-(1H-tetrazole-5-yl)-4-thiazolecarboxamide (372.9 mg, 97%), m.p. 278°-280° C. (from methanol-THF-water).

Provenance & Evidence