反应详情

To the mixture of dibromoformaldoxime (5 g, 24.63 mole) and propionyl chloride (2.31 g, 25 mole) in dry methylene chloride (30 ml) is slowly added dry pyridine (2 g, 25.5 mole) over 10 min at 0° to 5° C. with stirring. After addition the reaction mixture is stirred at 5° C. for 30 min and at 25° C. for another 30 min. The resultant suspension is diluted with methylene chloride and washed with water and brine. The organic layer is dried over MgSO4. Evaporation of solvent affords 5.44 g (85% of theory) of O-propionyldibromoformaldoxime as a light yellow liquid. NMR spectrum shows this to be the desired compound.

1. additionAfter addition the reaction mixture
2. stirringis stirred at 5° C. for 30 min and at 25° C. for another 30 min
3. washwashed with water and brine
4. dry with materialThe organic layer is dried over MgSO4
5. customEvaporation of solvent