HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Acetylthiomethyl-3-phenyl-propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-[(Acetylthio)methyl]-3-phenylpropionic Acid | HCID 9991796 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Acetylthiomethyl-3-phenyl-propionyl chloride | HCID 10377734 | — |
Reaction Steps
Dissolve 10 g (42 mmole) of 2-acetylthiomethyl-3-phenyl propionic acid and 10 g (84 mmole) of thionyl chloride in 50 ml of toluene. Stir for 10 hrs. under nitrogen and concentrate in vacuo. Dissolve the residue in 50 ml of toluene and again concentrate in vacuo. Repeat this step five times to obtain the product as a light brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04879309 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-856f4f1fab83410297a8ab8da646fb4e |
| Source note | uspto-grants-1989_11 |