Methyl Isocyanate → HCID 9936582, compound

Participants

Reaction Steps

Using 300 mg (0.60 m-mol) of (2S,4S)-4-dicyclohexylphosphinyl-2-diphenylphosphinylmethylpyrrolidine, the reaction and after-treatment were carried out in the same manner as described in Example 2(b) to obtain CPM. This CPM was dissolved in 8 ml of methylene chloride and 38 mg (0.66 m-mol) of methyl isocyanate was slowly added dropwise to the solution under ice-cooling. The mixture was stirred in a stream of argon for 2 hours at room temperature. The reaction liquid was concentrated at a lower temperature under reduced pressure, and the residue was dried. This product was recrystallized from methanol to obtain 292 mg (yield: 96%) of MCCPM as white crystals.

Provenance & Evidence