Methanol → Ethyl 3-Hydroxybutyrate

Participants

Reaction Steps

To 3.90 g of ethyl acetoacetate were added 7.4 mg of rhodium 1,5-cyclooctadiene chloride complex compound, 22.1 mg of BCPM and 10 ml of methanol, and the mixture was charged into an autoclave. The mixture was stirred in the autoclave for 45 hours at 50° C. in hydrogen atmosphere at an initial pressure of 50 atm. It was confirmed by gas chromatography that 100% of the starting material had been converted. After distilling off the solvent, ethyl β-hydroxybutyrate was obtained almost theoretically by distillation under reduced pressure. [α]D23 =-2.67° (neat) (optical yield: 26%).

Provenance & Evidence