HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methyl-2-piperidone → 1-(3-Chlorophenyl)-3-(1-methyl-2-piperidylidene)-2(1H,3H)-indolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methyl-2-piperidone | HCID 13603 | — |
| Reactant | 1-(3-Chlorophenyl)-indolin-2-one | HCID 11299530 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-(3-Chlorophenyl)-3-(1-methyl-2-piperidylidene)-2(1H,3H)-indolone | HCID 53732437 | — |
Reaction Steps
By the procedure of Example B1, but using 1:1 hexane:ethyl acetate as chromatography eluant and pentane for crystallization, 1-(3-chlorophenyl-2-(1H,3H)-indolone (2.0 g, 8.2 mmoles) and N-methyl-2-piperidone (1.3 ml, 11.5 mmoles) were converted to title product, 180 mg (6.5%) m.p. 162°-165°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04879391 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-64224024a6b74cdc82f5ac1522e51601 |
| Source note | uspto-grants-1989_11 |