Dimethylformamide → HCID 17995130, compound

Participants

Reaction Conditions

Reaction Steps

2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine (10 mmol) was dissolved in dry DMF (15 ml) and charged with sodium hydride (13 mmol. The resulting solution was cooled under N2 to -20° C., whereafter chlordiethylphosphate (13 mmol) was added. The reaction mixture was kept under N2 with stirring at -20° C. and was charged with a -30° C. cold solution of 5-ethyl-3-isocyano-methyl-1,2,4-oxadiazol (13 mmol) and K-t-butylate (13 mmol) in dry DMF (10 ml). The resulting reaction mixture was allowed to heat to room temperature, whereafter 5 ml of glacial acetic acid was added. The resulting mixture was filtered which gave 0.36 g of the title compound. M.p. 150.7°-150.8° C.

Provenance & Evidence