Azobisisobutyronitrile → HCID 19841102, compound

Participants

Reaction Steps

To a mixture 0.55 g of 2-butyl-1-[(2'-carboxymethylbiphenyl-4-yl)methyl]benzimidazole-6-carboxaldehyde in 30 mL of carbon tetrachloride was added 0.23 g of N-bromosuccinimide and a catalytic amount of azobisisobutyronitrile. The reaction was stirred at room temperature until the reaction went to completion and then concentrated to dryness. The residue was partitioned between ethyl acetate and water. The organic phase was washed with water, dried and concentrated. Flash column chromatography (silica gel; 1:1 hexane/ethyl acetate to 1:3 hexane/ethyl acetate) afforded 0.45 g of the product as a thick clear oil.

Provenance & Evidence