反应详情

737 Milligrams of 2-chloro-imidazo[4,5-b]pyridine, 0.4 g of thiourea and 20 ml of ethanol were mixed together and this mixture was refluxed for 2 hours. Next, 666 mg of 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride was added to the reaction mixture and refluxed for 5 hours. After the reaction was completed, ethanol was removed by evaporation, then to the residue thus obtained was added water and this solution was extracted with chloroform. The chloroform extract was dried with anhydrous magnesium sulfate and chloroform was removed by evaporation. The residue thus obtained was recrystallized from ethanol to obtain 450 mg of 2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]imidazo[4,5-b]pyridine in the form of white powdery crystals. Melting point: 186°-188° C.

1. temperaturethis mixture was refluxed for 2 hours
2. temperaturerefluxed for 5 hours
3. customethanol was removed by evaporation
4. customto the residue thus obtained
5. extractionthis solution was extracted with chloroform
6. extractionThe chloroform extract
7. dry with materialwas dried with anhydrous magnesium sulfate and chloroform
8. customwas removed by evaporation
9. customThe residue thus obtained
10. customwas recrystallized from ethanol