反应详情

To a solution of 2-amino-4,5-difluoro-3-methylthiomethylbenzonitrile (4.0 g) in ethanol (80 ml) are added Raney nickel (40 ml) with ethanol (80 ml). The mixture is stirred at 40°-50° C. for 30 minutes, and then filtered. To the filtrate is added water, the reaction mixture is extracted with ethyl acetate. The extract is dried over magnesium sulfate and concentrated. The product is recrystallized from n-hexane to give 2-amino-4,5-difluoro-3-methylbenzonitrile (2.4 g), as a white crystal, m.p. 114°-116° C.

1. filtrationfiltered
2. additionTo the filtrate is added water
3. extractionthe reaction mixture is extracted with ethyl acetate
4. dry with materialThe extract is dried over magnesium sulfate
5. concentrationconcentrated
6. customThe product is recrystallized from n-hexane