HCID 19841134, compound → HCID 19841155, compound

Participants

Reaction Steps

To 1-cyclopropyl-7-(4-benzyl-1-piperazinyl)-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (132 mg) are added 10% Pd-C (68 mg) and ethanol (10 ml), and the mixture is subjected to catalytic reduction under hydrogen gas atmosphere at 60° C. for 6.5 hours. After filtering off the catalyst, the filtrate is concentrated. The resulting residue is recrystallized from ethanol-acetone-dichloromethane to give 1-cyclopropyl-7-(1-piperazinyl)-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (34.2 mg), as white powder, m.p. 149°-152° C.

Provenance & Evidence