4-Nitrophenol → HCID 53757149, compound

Participants

Reaction Steps

To a solution of the chloro derivative from Step 2 (6.5 g, 13.2 mmol) and p-nitrophenol (1.95 g, 14.0 mmol) in dimethylformamide (75 mL) was added 60% sodium hydride mineral oil suspension (0.56 g, 14.0 mmol). The resulting solution was stirred at 60° under nitrogen for 19 hours. After concentrating under reduced pressure at 60° , the residue was partitioned between ethyl acetate and brine. The organic extract was dried (Na2SO4) filtered and concentrated. The residue was flash chromatographed over silica gel and 6.8 g of pure product was eluted with 15% ethyl acetate - 85% n-butylchloride.

Provenance & Evidence