Succinic anhydride → HCID 135968533, compound

Participants

Reaction Steps

A solution of (S)-9-(2,3-dihydroxy-1propoxymethyl)guanine (1.37 g, 5 mmol), 2.0 g of succinic anhydride, and 2.8 ml of anhydrous triethylamine in dry dimethylformamide (75 ml) is heated in an oil bath at 60° . When the reaction is complete (24 hours) the mixture is cooled and evaporated to dryness in vacuo. The residue is resuspended in ice-water (50 ml) and the pH is adjusted to 2 with 2N-HCl. The precipitate is filtered, thoroughly washed with ice-water, and dried in vacuo. The precipitate is then recrystallized from methanol.

Provenance & Evidence