Calcium Hydroxide → Calcium sulindac

HRID 1638729Notes

Reaction equation

HRID 1638729 reaction equation
[CH3:1][C:2]1=[C:3]([CH2:22][C:23]([OH:25])=[O:24])[C:4]2[CH:5]=[C:6]([F:21])[CH:7]=[CH:8][C:9]=2/[C:10]/1=[CH:11]\[C:12]1[CH:13]=[CH:14][C:15]([S+:18]([O-:20])[CH3:19])=[CH:16][CH:17]=1.[OH-].[Ca+2:27].[OH-]>C(O)C>[Ca:27].[CH3:1][C:2]1=[C:3]([CH2:22][C:23]([OH:25])=[O:24])[C:4]2[CH:5]=[C:6]([F:21])[CH:7]=[CH:8][C:9]=2/[C:10]/1=[CH:11]\[C:12]1[CH:13]=[CH:14][C:15]([S+:18]([O-:20])[CH3:19])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6093208Calcium HydroxideHCID 178427217HCID 178427217, compound

Product 1

HCID 178427218Calcium sulindac

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 g Sulindac is suspended in 4 l. of 75% v/v ethanol. Apply heat until a clear solution is formed. Add 10.38 g of calcium hydroxide and mix. A clear solution is formed initially followed by massive precipitation of calcium sulindac. Filter the slurry to remove the solvent and air dry to give calcium sulindac.

Workup

  1. temperatureApply heat until a clear solution
  2. customis formed
  3. additionmix
  4. customA clear solution is formed initially
  5. customfollowed by massive precipitation of calcium sulindac
  6. filtrationFilter the slurry
  7. customto remove the solvent and air
  8. customdry

Sources & evidence

ORD record
ord-2816768c24204fd592746419257cd323
Source dataset
uspto-grants-1989_11
Patent number
US04880835

Reaction notes

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