HCID 19841303, compound → HCID 19841355, compound

Participants

Reaction Steps

In the described fashion as Example 21 (b and c), replacing ethyl 1-ethyl-6-fluoro-7-acetyl-1,4-dihydro-4-oxo-quinoline carboxylate (9) (A=CH, R10 =C2H5, R=C2H5) with 1-cyclopropyl-2-methylthio-6-fluoro-7-acetyl-1,4-dihydro-4-oxo-3-carboxylate (13) of Example 40 and also replacing the catalyst Raney nickel catalyst in Example 21(c) with pallidium on carbon under an hydrogen atmosphere, one can obtain ethyl 1-cyclopropyl-2-methylthio-6-fluoro-7-(3-aminocyclopentyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylate (16) (A=CH, R11 =CH3, R10 =C2H5, R=cyclopropyl, Z= ##STR137##

Provenance & Evidence