反应详情

Using 7-methoxy-1,2-dihydro-3-naphthoic acid (0.5 g), 1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (1.1 g), triethylamine (0.81 g), N,N-dimethylformamide (20 ml) and diethyl phosphorocyanidate (1 ml), an amidation is carried out in a manner as that described in Example 6. The reaction product is purified by silica gel column chromatography (hexane:acetone=1:1-1:2) to afford an oily product, which is converted to the hydrochloride in ethyl acetate to give 1-(7-methoxyethoxy-1,2-dihydro-3-naphthoyl)- 4-(3,4,5-trimethoxybenzyl)piperazine hydrochloride (0.8 g) as colorless crystals, m.p. 187°-190° C.

1. customThe reaction product is purified by silica gel column chromatography (hexane:acetone=1:1-1:2)
2. customto afford an oily product, which