1-(3,4,5-Trimethoxybenzoyl)piperazine → HCID 10006552, compound

HRID 1638811Notes

Reaction equation

HRID 1638811 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]2[CH:7]=[C:8]([C:12]([OH:14])=O)[CH2:9][CH2:10][CH2:11][C:5]=2[C:4]=1[O:17][CH3:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:32]=[C:33]([O:37][CH3:38])[C:34]=1[O:35][CH3:36])[C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)=[O:25]>>[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]2[CH:7]=[C:8]([C:12]([N:29]3[CH2:30][CH2:31][N:26]([C:24](=[O:25])[C:23]4[CH:32]=[C:33]([O:37][CH3:38])[C:34]([O:35][CH3:36])=[C:21]([O:20][CH3:19])[CH:22]=4)[CH2:27][CH2:28]3)=[O:14])[CH2:9][CH2:10][CH2:11][C:5]=2[C:4]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 28742041-(3,4,5-Trimethoxybenzoyl)piperazineHCID 10467188HCID 10467188, compound

Product 1

HCID 10006552HCID 10006552, compound

Procedure

In a manner as that described in Example 62, 3,4-dimethoxy-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid and 1-(3,4,5-trimethoxy-benzoyl)piperazine are subjected to amidation to give 1-(3,4-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine. This product is recrystallized from ethyl acetate to give colorless prisms, m.p. 133°-134° C.

Sources & evidence

ORD record
ord-57f5c22df4cb44f6a55f559831b56e87
Source dataset
uspto-grants-1989_11
Patent number
US04880809

Reaction notes

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