HCID 70399831, compound → HCID 18635810, compound

Participants

Reaction Steps

A solution of 3.30 g of (E)-3'-O-acetyl-5'-[3-(2,6-dichlorophenyl)-2-oxopropylidene]-2',5'-dideoxy-5-ethyluridine in 1.50 l of methanol was hydrogenated over 1.10 g of 10% Pd/C catalyst at room temperature and under atmospheric pressure for 3 hours. The mixture was filtered and the filtrate was evaporated. The residue was triturated with diethyl ether to give 2.45 g of 3'-O-acetyl-5'-[3-(2,6-dichlorophenyl)-2-oxopropyl]-2',5'-dideoxy-5-ethyluridine, mp 186°.

Provenance & Evidence