Methanesulfonyl chloride → HCID 18635820, compound

Participants

Reaction Steps

A solution of 300 mg of 3'-O-acetyl-5'-[2(RS)-hydroxy-3-phenylpropyl]-2',5'-dideoxy-5-ethyluridine and 0.2 ml of methanesulphonyl chloride in 5 ml of pyridine was left to stand at 0° C. overnight. The mixture was poured on to 40 ml of ice/water, stirred and extracted with 40 ml of ethyl acetate. The extract was dried over anhydrous sodium sulphate and evaporated to yield 330 mg of 3'-O-acetyl-2',5'-dideoxy-5-ethyl-5'-[2(RS)-methanesulphonyloxy-3-phenylpropyl]uridine.

Provenance & Evidence