Isopropyl iodide → HCID 13772342, compound

Participants

Reaction Steps

35.4 g (0.14 mol) of 3-(2-methoxyphenyl)-1-methylindolin- -2-one in 350 ml of dry THF are stirred with 16.1 g (0.14 mol) of potassium tertiary-butylate at room temperature for 15 minutes. Then at 10° C., a solution of 14.3 ml of 2-iodopropane in 70 ml of dry THF are added dropwise, and the mixture is then stirred at room temperature for 4 hours. The reaction mixture is left to stand overnight and then partitioned between water and ethyl acetate. After the organic phase has been evaporated, 4.8 g of product of melting point 113°-115° C. are obtained.

Provenance & Evidence