Boron tribromide → HCID 13772344, compound

Participants

Reaction Steps

A solution of 1.92 ml (0.02 mol) of boron tribromide in 20 ml of methylene chloride is added dropwise over the course of 1 hour to 5.9 g (0.02 mol) of 3-isopropyl-3-(2-methoxyphenyl)-1-methylindolin-2-one in 75 ml of methylene chloride at 0° C. After 30 minutes, the mixture is poured onto ice-water, and the organic phase is washed with water, dried and evaporated. The residue is triturated with cold toluene and is filtered off with suction. 4.8 g, melting point 172°-174° C.

Provenance & Evidence