HCID 14675914, compound → HCID 14675920, compound

HRID 1638990Notes

Reaction equation

HRID 1638990 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][O:19][CH2:20][C@@H:21]([C:30]([OH:32])=[O:31])NC(OC(C)(C)C)=O)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:40]C(N1CCC(CCOC[C@H](C(O)=O)NC(OC(C)(C)C)=O)CC1)=O)C1C=CC=CC=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH2:13][CH:14]([CH2:17][CH2:18][O:19][CH2:20][C@H:21]([OH:40])[C:30]([OH:32])=[O:31])[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14675914HCID 14675914, compoundHCID 14675915HCID 14675915, compound

Product 1

HCID 14675920HCID 14675920, compound

Procedure

0.5 g of O-[2-(1-benzyloxycarbonyl-4-piperidyl)ethyl]-N-(tert-butoxycarbonyl)-L-serine, in place of O-[2-(1-benzyloxycarbonyl-4-piperidyl)ethyl]-N-(tert-butoxycarbonyl)-D-serine, is subjected to the same reaction procedure and purification treatment as in Reference Example 7 to give 380 mg of 3-[2-(1-benzyloxycarbonyl-4-piperidyl)ethoxy]-2(S)-hydroxypropionic acid as an oily substance.

Sources & evidence

ORD record
ord-3a7b2eb1293b4fd6809dfbce02c5e44a
Source dataset
uspto-grants-1989_11
Patent number
US04882326

Reaction notes

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