HCID 14675919, compound → HCID 14600709, compound

HRID 1638991Notes

Reaction equation

HRID 1638991 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][S:19][CH2:20][C@@H:21]([OH:25])[C:22]([OH:24])=[O:23])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:26](OC(N1CCC(CCOC[C@@H](O)C(O)=O)CC1)=O)[C:27]1C=CC=CC=1>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][S:19][CH2:20][C@@H:21]([OH:25])[C:22]([O:24][CH2:26][CH3:27])=[O:23])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14675919HCID 14675919, compoundHCID 14675934HCID 14675934, compound

Product 1

HCID 14600709HCID 14600709, compound

Procedure

3.7 g of 3-[2-(1-benzyloxycarbonyl-4-piperidyl)ethylthio]-2(S)-hydroxypropionic acid, in place of 3-[2-(1-benzyloxycarbonyl-4-piperidyl)ethoxy]-2(R)-hydroxypropionic acid, is subjected to the same reaction and treatment procedures as in Reference Example 9 to give 2.0 g of oily ethyl 3-[2-(1-benzyloxycarbonyl-4-piperidyl)ethylthio]-2(S)-hydroxypropionate.

Sources & evidence

ORD record
ord-c6dbf1f81d8746f492b3d24a559ba052
Source dataset
uspto-grants-1989_11
Patent number
US04882326

Reaction notes

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