反应详情

A suspension of (3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester (800 mg) and 10% palladium-carbon (79.2 mg, 50% water content) in ethanol (15 mL) was stirred under a hydrogen atmosphere for 15 minutes. The catalyst was filtered off over Celite. The obtained filtrate was concentrated, to thereby obtain the titled compound (529 mg). The physical properties of the compound were as follows.

1. filtrationThe catalyst was filtered off over Celite
2. concentrationThe obtained filtrate was concentrated