Dimethyl Sulfate → HCID 14722247, compound

HRID 1639018Notes

Reaction equation

HRID 1639018 reaction equation
[CH:1]1([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[C:10](=[O:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(OC)(O[CH3:24])(=O)=O>[OH-].[Na+]>[CH:1]1([N:7]=[C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[C:10]([O:19][CH3:24])=[CH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 14722230HCID 14722230, compound

Product 1

HCID 14722247HCID 14722247, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 9.0 g of 4-(cyclohexylamino)-1,2-naphthoquinone in 200 ml of dimethyl sulfate and 460 ml of 30% aqueous sodium hydroxide is heated slowly to reflux. The reaction mixture is stirred for 6 hours, washed with 300 ml of water and dried at 80° C. under vacuo to yield 4-cyclohexylimino-1-oxo-2-methoxy-1,4-dihydronaphthalene, m.p. 145°-147° C.

Workup

  1. temperatureto reflux
  2. washwashed with 300 ml of water
  3. customdried at 80° C. under vacuo

Sources & evidence

ORD record
ord-8e3377d50b7c41d091774b641a2de66f
Source dataset
uspto-grants-1989_11
Patent number
US04882339

Reaction notes

Loading…