反应详情

温度

70 °C

2-Phenylbenzofuran-7-carboxylic acid (40 g) is dissolved in tetrahydrofuran (300 ml) and the solution is added dropwise to a suspension of lithium aluminum hydride (19.12 g) in tetrahydrofuran (130 ml) under ice-cooling. After the mixture is stirred at 70° C. for 2 hours, water is added to the mixture to decompose excess lithium aluminum hydride and its complex. Insoluble materials are filtered off, and the filtrate is concentrated under reduced pressure to remove solvent. The residue is dissolved in ethyl acetate, and the solution is washed with water, dried and concentrated under reduced pressure to remove solvent. The residue is recrystallized from a mixture of ethyl acetate and n-hexane, whereby 7-hydroxymethyl-2-phenylbenzofuran (34.4 g) is obtained. Yield: 91%.

1. temperaturecooling
2. filtrationInsoluble materials are filtered off
3. concentrationthe filtrate is concentrated under reduced pressure
4. customto remove solvent
5. dissolutionThe residue is dissolved in ethyl acetate
6. washthe solution is washed with water
7. customdried
8. concentrationconcentrated under reduced pressure
9. customto remove solvent
10. customThe residue is recrystallized from a mixture of ethyl acetate and n-hexane