HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Chloro-3-formyl-2-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-Chlorosalicylic Acid | HCID 9447 | — |
| Product | 5-Chloro-3-formyl-2-hydroxybenzoic acid | HCID 183356 | — |
Reaction Steps
A solution of 5-chloro-2-hydroxybenzoic acid (102 g) and hexamethylenetetramine (166 g) in trifluoroacetic acid is heated overnight. Dilute hydrochloric acid is added to the mixture and the mixture is heated. After cooling, the precipitates are collected by filtration, whereby 5-chloro-3-formyl-2-hydroxybenzoic acid (96.9 g) is obtained. m.p. 218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04882340 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-a8a374cff0034e15b061014554e6aea7 |
| Source note | uspto-grants-1989_11 |