反应详情

温度

60 °C

A mixture of 5 g of 5-hydroxy-pyrrolidin-2-one 2.5 g of Amberlite IR 120H in 100 cm3 of n-nonanol is agitated at 60° C. for 3 hours. It is then cooled. the resin is filtered off, and the solvent is eliminated by distilling at 70° C. under 0.5 mbar. The residue is taken up in 50 cm3 of n-hexane, which is maintained for 16 hours at 5° C. After separating, 6.8 g of the expected product is obtained, m.p. 46°-48° C. After recrystallizing from n-hexane, m.p. 51°-52° C.

1. temperatureIt is then cooled
2. filtrationthe resin is filtered off
3. distillationby distilling at 70° C. under 0.5 mbar
4. temperaturewhich is maintained for 16 hours at 5° C
5. customAfter separating