3,4-Dichloroaniline → 1-(3,4-Dichlorophenyl)piperazine

Participants

Reaction Steps

This compound was prepared according to the procedure of Preparation 1. A mixture of 44.6 g (0.25 mole) of bis(2-chloroethyl)amine hydrochloride, 40.5 g (0.25 mole) of 3,4-dichloroaniline and 50.0 g (0.36 mole) of potassium carbonate in a total volume of 500 ml of n-butanol gave an oil as residue. Trituration of the oil with petroleum ether (30°-60° C.) gave 16.0 g (28%) of white solid, m.p. 62°-65° C.

Provenance & Evidence