1-Phenylpiperazine → HCID 13120460, compound

Participants

Reaction Steps

A mixture of 18.72 g (0.075 mole) of 1-(4-chloro-2-methylphenoxy)-2-hydroxybutyl chloride, 16.2 g (0.1 mole) of N-phenylpiperazine and 350 ml of 2-propanol was heated at reflux for 16 hr. The white crystalline precipitate which formed on standing at room temperature was filtered. The resulting white crystalline solid was identified as the hydrochloride salt of the N-phenylpiperazine. The filtrate was mixed with 60 ml of ethereal hydrogen chloride and precipitated in ether. The white crystalline solid was filtered off and recrystallized with acetone to give 17.6 g of title compound, m.p. 186°-188° C.

Provenance & Evidence