Potassium Iodide → Hydrochloric Acid

Participants

Reaction Steps

This compound was prepared according to the procedure of Example 25. A mixture of 7.3 g (0.03 mole) of -4-(4-chloro-2-hydroxybutoxy)benzamide, 5.0 g (0.03 mole) of 1-phenylpiperazine, 16.0 g (0.15 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in a total volume of 200 ml of 1-butanol gave a cream colored semi-solid as residue. The hydrochloric acid salt was formed in 2-propanol saturated with hydrogen chloride, and the collected solid was recrystallized from methanol-water to give 4.8 g (40%) of white solid, m.p. 238°-241° C.

Provenance & Evidence