HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| Reactant | 4-Chloro-1-(4-chloro-3-methylphenoxy)-2-butanol | HCID 13323908 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 1-(4-Chloro-3-methylphenoxy)-4-[4-(4-fluorophenyl)-1-piperazinyl]-2-butanol | HCID 14422854 | — |
Reaction Steps
This compound was prepared according to the procedure of Example 25. A mixture of 1.8 g (0.01 mole) of 1-(4-fluorophenyl)piperazine, 2.5 g (0.01 mole) of 4-chloro-1-(4-chloro-3-methylphenoxy)-2-butanol, 5.2 g (0.05 mole) of anhydrous sodium carbonate and 0.1 g of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloride was formed in 2-propanol saturated with hydrogen chloride and the collected solid was recrystallized from methanol-water-ethyl ether to give 1.7 g (36%) of white solid, m.p. 199°-203° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04882330 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-6a9da974fc664503800d0366fcf4f547 |
| Source note | uspto-grants-1989_11 |