Methanol → HCID 14153046, compound

Participants

Reaction Steps

3.0 g. of the 5-(2-formylaminomethyl)prop-2-yl)-2-(4-pyridinyl)-benzimidazole prepared in Example 2 are hydrogenated in 50 ml. methanol in the presence of 1 ml. glacial acetic acid and 1 g. 10% palladium on charcoal for 6 hours at 50° C. and 5 bar hydrogen pressure. The reaction mixture is filtered, the filtrate is evaporated in a vacuum, the residue is digested with ethyl acetate, filtered off with suction and the residue is dissolved in 40 ml. hot dimethylformamide and filtered. After cooling, the filtrate is mixed with the same amount of ethyl acetate. After crystallisation, the product is filtered off with suction and washed with ethyl acetate to give 1.8 g. (59% of theory) of the title compound as colourless crystals; m.p. 234°-237° C.

Provenance & Evidence