Triethylamine → 1-Adamantan-1-yl-3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-urea; dihydrochloride

Participants

Reaction Steps

To a stirred suspension of 1-adamantanamine hydrochloride (1.0 gm, 0.0053 mol) and triethylamine (2.2 gm, 0.021 mol) in 25 ml of dry methylene chloride under a dry nitrogen atmosphere was added, dropwise, trichloromethyl chloroformate (1.15 gm, 0.0027 mol). The resulting suspension was refluxed for three hours, and then a solution of 3-[4-(3-chlorophenyl)-1-piperazinyl]propylamine (1.35 gm, 0.0053 mol) in 15 ml of dry methylene chloride was added. The resulting mixture was allowed to stir at room temperature overnight. The reaction mixture was then diluted to 200 ml with methylene chloride, washed with 3% aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and concentrated on a rotary evaporator. The title compound (TLC on silica gel using a 20% methanol in ethyl acetate solvent system, Rf=0.42) was isolated by gravity chromatography on silica gel and recrystallized from methylene chloride/hexane (1.52 gm, 61% of theory), mp.=174°-175° C.

Provenance & Evidence