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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1639167Generated: October 31, 2026

(Methylthio)acetic acid → Diethyl 2-[(methylsulfenylacetyl)amino]malonate

https://huagongshe.com/reaction/1639167

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Methylthio)acetic acidHCID 75551—
ReactantPropanedioic acid, 2-amino-, 1,3-diethyl esterHCID 81272—
ProductDiethyl 2-[(methylsulfenylacetyl)amino]malonateHCID 1509645268.4%

Reaction Steps

Diethyl 2-aminomalonate (3.5 g) and methylsulfenylacetic acid (2.2 g) are treated in the same manner as described in Reference Example 1 to give diethyl 2-[(methylsulfenylacetyl)amino]malonate (3.6 g), m.p. 56°-58° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04882447
Source datasetuspto-grants-1989_11
ORD IDord-bac6af6f27894778a169fc047b807f3b
Source noteuspto-grants-1989_11