HCID 53802218, compound → HCID 54193868, compound

Participants

Reaction Steps

Hydrolysis of the keto diester (16A) (158 mg) in the above manner gave the keto diol (5A) (74 mg, 74%), m.p. 205°-208° C. (from methanol, νmax 3600 (OH) and 1680 cm-1 (C=O), δ (250 MHz) 8.13 (1 H, dd, J 8 and 0.5 Hz, aromatic proton), 8.04 (1 H, dd, J 7 and 1,5 Hz, aromatic proton), 7.56 (1 H, dt, J 8 and 1.5 Hz, aromatic proton), 7.36 (1 H, dt, J 7 and 0.5 Hz, aromatic proton), 4.32 (1 H, ddd, J 10.5, 9.5, and 5 Hz, 11-proton), 3.79 (1 H, t, J 8 Hz, 17-proton), 2.77 (1 H, dd, J 17 and 3.5 Hz, 7-proton), 2.5 (1 H, t, J 10.5 Hz, 9-proton), 2.41-1.22 (11 H, m), 0.79 (3 H, s, 18-CH3), (Found: M 286.1572. C18H22O3 requires M 286.1567).

Provenance & Evidence