Bromine → 4-Bromo-2,6-difluoroaniline

HRID 1639188Notes

Reaction equation

HRID 1639188 reaction equation

[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:3]=1[NH2:4].[Br:10]Br>C(Cl)(Cl)Cl>[Br:10][C:7]1[CH:8]=[C:2]([F:1])[C:3]([NH2:4])=[C:5]([F:9])[CH:6]=1

Participants

4

Reactant 2

HCID 24408Bromine

HCID 796472,6-Difluoroaniline

Product 1

HCID 6101914-Bromo-2,6-difluoroaniline

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A 2,6-difluoroaniline (4) is reacted with bromine in chloroform to yield 4-bromo-2,6-difluoroaniline (5).

Sources & evidence

ORD record: ord-d6f1a18266f54d3abd630c55d7c1d817
Source dataset: uspto-grants-1989_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04883609

Reaction notes

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