HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroisatoic anhydride → 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroisatoic anhydride | HCID 329105 | — |
| Reactant | (4-Bromo-2-fluorophenyl)methanamine | HCID 3770848 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide | HCID 14458986 | 79.9% |
Reaction Steps
A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04883800 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-2b0428b207f84a6f9f4684210c20692a |
| Source note | uspto-grants-1989_11 |