Sodium Hydroxide → 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide	HCID 14458987	—
Catalyst	Iron	HCID 23925	—
Solvent	Acetic Acid	HCID 176	—
Product	2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide	HCID 14458995	98%

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.4 g) and iron (1.45 g) in acetic acid (66 ml) was stirred at 100° C. for 30 minutes. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (3.10 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04883800
Source dataset	uspto-grants-1989_11
ORD ID	ord-4eea3f8d26614eabaecd02eb0fccda4f
Source note	uspto-grants-1989_11