1,4-Dioxane → HCID 14459009, compound

HRID 1639302Notes

Reaction equation

HRID 1639302 reaction equation
[NH2:1][C:2]1[CH:19]=[C:18]([Br:20])[CH:17]=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[F:15])=[O:5].[O:21]1CCOC[CH2:22]1>>[Br:20][C:18]1[CH:19]=[C:2]2[C:3]([C:4](=[O:5])[N:6]([CH2:7][C:8]3[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=3[F:15])[C:22](=[O:21])[NH:1]2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 14458999HCID 14458999, compound

Product 1

HCID 14459009HCID 14459009, compound

Procedure

A mixture of 2-amino-4-bromo-N-(2-fluoro-4-iodobenzyl)benzamide (3.80 g), N,N'-carbonyldiimidazole (5.5 g) and 1,4-dioxane (30 ml) was refluxed for 2 hours. The resulting crystals were collected by filtration, washed with 1,4-dioxane and dried over phosphorus pentoxide to give 7-bromo-3-(2-fluoro-4-iodobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline (2.85 g).

Workup

  1. temperaturewas refluxed for 2 hours
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with 1,4-dioxane
  4. dry with materialdried over phosphorus pentoxide

Sources & evidence

ORD record
ord-6f45e3effe78484f85f60cbdbe3974bd
Source dataset
uspto-grants-1989_11
Patent number
US04883800

Reaction notes

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