1,4-Dioxane → HCID 14459011, compound

HRID 1639303Notes

Reaction equation

HRID 1639303 reaction equation
[C:1]([C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])(=[O:3])[NH2:2].[O:19]1CCOC[CH2:20]1>>[Cl:10][C:8]1[CH:9]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:11])[N:12]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:20](=[O:19])[NH:2][C:1]2=[O:3]

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 14458941HCID 14458941, compound

Product 1

HCID 14459011HCID 14459011, compound

Conditions

Temperature
140 °C

Procedure

Ethyl N-(2-carbamoyl-4,5-dichlorophenyl)aminoacetate (4.6 g) and N,N'-carbonyldiimidazole (5.12 g) were dissolved in dioxane (50 ml). The solution was evaporated to give a residue, which was stirred at 140° C. for 30 minutes. After cooling, the precipitates were collected by filtration and washed with ethanol to give ethyl 2-(6,7-dichloro-1,2,3,4-tetrahydro-2,4-dioxoquinazolin-1-yl)acetate (4.40 g).

Workup

  1. customThe solution was evaporated
  2. customto give a residue, which
  3. temperatureAfter cooling
  4. filtrationthe precipitates were collected by filtration
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-fa59764e2ed04690b0d693b8b4e97e39
Source dataset
uspto-grants-1989_11
Patent number
US04883800

Reaction notes

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