Acetone → HCID 13103229, compound

Participants

Reaction Steps

3.25 g (59.3 mM) of p-methoxybenzyl 7-benzylideneamino-3-iodomethyl-3-cephem-4-carboxylate was dissolved in 55 ml of 99% formic acid. Under cooling with ice, 23 ml of concentrated hydrochloric acid was added to this solution, and the mixture was stirred at room temperature for 1.5 hours. To the reaction solution, 200 ml of acetone and 400 ml of isopropyl ether were added. Precipitates were collected by filtration, washed with acetone and dried to obtain 12 g (yield: 53.7%) of 7-amino-3-iodomethyl-3-cephem-4-carboxylic acid hydrochloride.

Provenance & Evidence