Methylhydrazine → HCID 178459349, compound

HRID 1639325Notes

Reaction equation

HRID 1639325 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[N:5]([C:23](=[O:26])[NH:24][N:25]=2)[CH:6]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=2)[C:7]=1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].[CH3:27]NN>C(#N)C>[CH3:27][N:24]1[C:23](=[O:26])[N:5]2[C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=3)=[C:7]([C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9])[CH:2]([CH3:1])[N:3]=[C:4]2[NH:25]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 136454092HCID 136454092, compound

Product 1

HCID 178459349HCID 178459349, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title B compound of Example 1 (1 g, 2.0 mmol) in acetonitrile (7 ml) was cooled to 0° C. under argon and was treated with methylhydrazine (0.125 mL, 3.2 mmol). The reaction turned yellow instantaneously and a light yellow solid precipitated out. The reaction was allowed to stir at room temperature for 45 minutes and the solid was then filtered off and washed with acetonitrile to provide the title compound (620 mg) as a light yellow solid, m.p. 255°-256° C.

Workup

  1. customa light yellow solid precipitated out
  2. filtrationthe solid was then filtered off
  3. washwashed with acetonitrile

Sources & evidence

ORD record
ord-0d584378babb41cf8adff1ed662ea72f
Source dataset
uspto-grants-1989_11
Patent number
US04883872

Reaction notes

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