HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylamide → 8-chloro-1,4,5,6-tetrahydrobenzo[f]quinolin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylamide | HCID 6579 | — |
| Reactant | Pyrrolidine, 1-(6-chloro-3,4-dihydro-2-naphthalenyl)- | HCID 10444008 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-chloro-1,4,5,6-tetrahydrobenzo[f]quinolin-3(2H)-one | HCID 10466539 | — |
Reaction Steps
701 g (3 mol) of 1-(6-chloro-3,4-dihydro-2-naphthyl)-pyrrolidine and 640 g (19 mol) of acrylamide in 7 ml of ethanol are boiled under reflux for 3 days with the addition of 70 g of Amberlite IR200. The separated solid is removed by filtration, extractively crystallized with dioxane and there is obtained 8-chloro-1,4,5,6-tetrahydrobenzo[f]-quinolin-3(2H)-one with melting point 228°-230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04883815 |
| Source dataset | uspto-grants-1989_11 |
| ORD ID | ord-cc85e2db7142473394fe502977c273ba |
| Source note | uspto-grants-1989_11 |