Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetramethoxysilane → 8-Chloro-1,1-dimethyl-1,2,5,6-tetrahydrobenzo[f]quinolin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetramethoxysilane | HCID 12682 | — |
| 반응물 | Senecioic acid amide | HCID 20560 | — |
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | 6-Chloro-2-tetralone | HCID 4456139 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 8-Chloro-1,1-dimethyl-1,2,5,6-tetrahydrobenzo[f]quinolin-3-one | HCID 54328780 | — |
반응 단계
A suspension of 127 g (0.7 mol) of 6-chloro-2-tetralone, 70.0 g (0.7 mol) of 3,3-dimethylacrylamide, 63.6 ml (0.42 mol) of tetramethoxysilane and 85.3 g (0.56 mol) of cesium fluoride in 400 ml of toluene is boiled under reflux for 18 hours. Distillation of the solvent in a vacuum, extraction with methylene chloride/water, chromatography on silica gel with ethyl acetate/hexane (1:1) and recrystallization from methylene chloride/hexane yields 8-chloro-1,1-dimethyl-1,2,5,6-tetrahydrobenzo[f]-quinolin-3-one as white crystals with melting point 213°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04883815 |
| 출처 데이터셋 | uspto-grants-1989_11 |
| ORD ID | ord-39b1ec7db3924361b20b3a6b56eab709 |
| 출처 메모 | uspto-grants-1989_11 |