Sodium borohydride → HCID 19833124, compound

Participants

Reaction Steps

0.38 g (0.01 mol) of sodium borohydride is added to a solution of 3.25 g (0.01 mol) of methyl 2-(4-acetamidobutyryl)-5-chloro-hydrocinnamate in 35 ml of methanol and the mixture is stirred at room temperature for 1 hour. The solution is concentrated, extracted with methylene chloride/water, dried with magnesium sulfate and the solvent is distilled in a vacuum. Chromatography on silica gel with chloroform-methanol (20:1) gives methyl 2-(4-acetamido-1-hydroxybutyl)-5-chlorohydrocinnamate as a yellow oil.

Provenance & Evidence