Hydrochloric Acid → HCID 19833168, compound

Participants

Reaction Steps

120 ml of 2N hydrochloric acid are added to a solution of 23.8 g (0.06 ml) of N-[3-[(11-chloro-2,3,5,6,7,8-hexahydro-3,8-dioxo-4-benzazecin-4(1H)-yl)-carbonyl]propyl]acetamide in 240 ml of tetrahydrofuran and the mixture is stirred at room temperature for 8 days. The solution is concentrated, extracted with methylene chloride/water, dried with magnesium sulfate and the solvent is distilled in a vacuum. Recrystallization from methanol/ether gives 2-[4-(4-acetamidobutyramido)butyryl]-5-chlorohydrocinnamic acid as beige crystals with melting point 108°.

Provenance & Evidence