Hydrazine hydrate (1:1) → HCID 19833172, compound

Participants

Reaction Steps

A suspension of 11.85 g (0.035 mol) of 8-chloro-N-(chloroacetyl)-2,3,5,6-tetrahydrobenzo[f]quinoline-4(1H)-carboxamide and 4.4 ml (0.091 mol) of hydrazine hydrate in 250 ml of ethanol is stirred at room temperature for 3 hours, concentrated in a vacuum and extracted with methylene chloride/water. Drying with magnesium sulfate and distillation of the solvent in a vacuum yields 8-chloro-2,3,5,6-tetrahydrobenzo[f]quinoline-4(1H)-carboxamide as white crystals which exhibit a melting point of 169°-171° after recrystallization from methylene chloride.

Provenance & Evidence