Sodium Hydroxide → HCID 19839076, compound

HRID 1639403Notes

Reaction equation

HRID 1639403 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:14][CH:12]([CH2:13]2)[C:11](=O)[N:10]([CH3:16])[C:9]3=O)=[CH:4][CH:3]=1.[OH-].[Na+]>C1(C)C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]23[CH2:14][CH:12]([CH2:13]2)[CH2:11][N:10]([CH3:16])[CH2:9]3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19839072HCID 19839072, compound

Product 1

HCID 19839076HCID 19839076, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Analogously to Example 1a), 3.9 g of 1-(4-chlorophenyl)-3-methyl-3-azabicyclo[3.1.1]heptane-2,4-dione in 70 ml of toluene are reacted with 25 ml of a toluene solution of sodium dihydro-bis-(2-methoxyethoxy)aluminate (70%; FLUKA) and the mixture is worked up with 25 ml of concentrated sodium hydroxide solution. m.p. of the title compound: 180-182° C.

Sources & evidence

ORD record
ord-2536789602a4465c9ecf84932cf1a28e
Source dataset
uspto-grants-1989_11
Patent number
US04883877

Reaction notes

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