3-Phenylprop-2-enoyl chloride → HCID 3760131, compound

HRID 1639418Notes

Reaction equation

HRID 1639418 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[C:7](Cl)(=[O:16])[CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(#N)C>[C:10]1([CH:9]=[CH:8][C:7]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 660233-Phenylprop-2-enoyl chlorideHCID 80519Methyl carbazate

Product 1

HCID 3760131HCID 3760131, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a solution of 27 g (0.3 moles) of methyl carbazate and 250 ml. of acetonitrile a solution of 50 g. (0.3 moles) of cinnamic chloride and 100 ml. of acetonitrile is added. The reaction mixture is heated to boiling for 15 hours. The mixture is cooled and the precipitated white crystals are filtered off. Thus 62.6 of the desired compound are obtained, yield 94.8%. M.p.: 165° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureThe mixture is cooled
  3. filtrationthe precipitated white crystals are filtered off

Sources & evidence

ORD record
ord-88d91b7900f745dbabe4a17912a30406
Source dataset
uspto-grants-1989_11
Patent number
US04883907

Reaction notes

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